2026-05-28T15:49:43Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/341782026-02-03T10:59:42Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Pérez-Luna, Ana Isabel author Rodríguez-Negrete, Edgar A. author Morilla, Gabriel author Wang, Liping author Lozano-Durán, Rosa author Castillo-Garriga, Araceli author Rodríguez-Bejarano, Eduardo author 2017-10-01 The suppression of gene silencing is a key mechanism for the success of viral infection in plants. DNA viruses from the Geminiviridae family encode several proteins that suppress transcriptional and post-transcriptional gene silencing (TGS/PTGS). In Begomovirus, the most abundant genus of this family, three out of six genome-encoded proteins, namely C2, C4 and V2, have been shown to suppress PTGS, with V2 being the strongest PTGS suppressor in transient assays. Beet curly top virus (BCTV), the model species for the Curtovirus genus, is able to infect the widest range of plants among geminiviruses. In this genus, only one protein, C2/L2, has been described as inhibiting PTGS. We show here that, despite the lack of sequence homology with its begomoviral counterpart, BCTV V2 acts as a potent PTGS suppressor, possibly by impairing the RDR6 (RNA-dependent RNA polymerase 6)/suppressor of gene silencing 3 (SGS3) pathway. Luna AP, Rodríguez-Negrete EA, Morilla G, Wang L, Lozano-Durán R, Castillo AG, Bejarano ER. V2 from a curtovirus is a suppressor of post-transcriptional gene silencing. J Gen Virol. 2017 Oct;98(10):2607-2614. doi: 10.1099/jgv.0.000933. Epub 2017 Sep 21. PMID: 28933688 https://hdl.handle.net/10630/34178 10.1099/jgv.0.000933 Virus fitopatógenos V2 from a curtovirus is a suppressor of post-transcriptional gene silencing