2026-05-30T08:37:45Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/341782026-02-03T10:59:42Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Pérez-Luna, Ana Isabel
author
Rodríguez-Negrete, Edgar A.
author
Morilla, Gabriel
author
Wang, Liping
author
Lozano-Durán, Rosa
author
Castillo-Garriga, Araceli
author
Rodríguez-Bejarano, Eduardo
2024-10-02T08:41:41Z
2024-10-02T08:41:41Z
2017-10-01
Luna AP, Rodríguez-Negrete EA, Morilla G, Wang L, Lozano-Durán R, Castillo AG, Bejarano ER. V2 from a curtovirus is a suppressor of post-transcriptional gene silencing. J Gen Virol. 2017 Oct;98(10):2607-2614. doi: 10.1099/jgv.0.000933. Epub 2017 Sep 21. PMID: 28933688
https://hdl.handle.net/10630/34178
10.1099/jgv.0.000933
The suppression of gene silencing is a key mechanism for the success of viral infection in plants. DNA viruses from the Geminiviridae family encode several proteins that suppress transcriptional and post-transcriptional gene silencing (TGS/PTGS). In Begomovirus, the most abundant genus of this family, three out of six genome-encoded proteins, namely C2, C4 and V2, have been shown to suppress PTGS, with V2 being the strongest PTGS suppressor in transient assays. Beet curly top virus (BCTV), the model species for the Curtovirus genus, is able to infect the widest range of plants among geminiviruses. In this genus, only one protein, C2/L2, has been described as inhibiting PTGS. We show here that, despite the lack of sequence homology with its begomoviral counterpart, BCTV V2 acts as a potent PTGS suppressor, possibly by impairing the RDR6 (RNA-dependent RNA polymerase 6)/suppressor of gene silencing 3 (SGS3) pathway.
eng
Virus fitopatógenos
V2 from a curtovirus is a suppressor of post-transcriptional gene silencing
journal article
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Luna2072JGV-postprintFinal.pdf