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oai:riuma.uma.es:10630/342622026-02-03T11:13:33Zcom_10630_2254col_10630_37953

A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens Medina-Puche, Laura Tan, Huang Vivek Dogra Wu, Mengshi Rosas-Díaz, Tábata Victoria Liping, Wang Xue, Ding Dan, Zhanga Xing Fu Chanhong Kim Lozano-Durán, Rosa Virus fitopatógenos Chloroplasts are crucial players in the activation of defensive hormonal responses during plant-pathogen interactions. Here, we show that a plant virus-encoded protein re-localizes from the plasma membrane to chloroplasts upon activation of plant defense, interfering with the chloroplast-dependent anti-viral salicylic acid (SA) biosynthesis. Strikingly, we have found that plant pathogens from different kingdoms seem to have convergently evolved to target chloroplasts and impair SA-dependent defenses following an association with membranes, which relies on the co-existence of two subcellular targeting signals, an N-myristoylation site and a chloroplast transit peptide. This pattern is also present in plant proteins, at least one of which conversely activates SA defenses from the chloroplast. Taken together, our results suggest that a pathway linking plasma membrane to chloroplasts and activating defense exists in plants and that such pathway has been co-opted by plant pathogens during host-pathogen co-evolution to promote virulence through suppression of SA responses. 2024-10-03T09:40:25Z 2024-10-03T09:40:25Z 2020-07 journal article Laura Medina-Puche, Huang Tan, Vivek Dogra, Mengshi Wu, Tabata Rosas-Diaz, Liping Wang, Xue Ding, Dan Zhang, Xing Fu, Chanhong Kim, Rosa Lozano-Duran, A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens, Cell, Volume 182, Issue 5, 2020, Pages 1109-1124.e25, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2020.07.020. https://hdl.handle.net/10630/34262 10.1016/j.cell.2020.07.020 spa http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier