2026-06-02T21:52:38Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/343032026-02-03T11:05:25Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Moreno-Gonzalez, Ines author Estrada, Lisbell D author Sánchez-Mejías, Elisabeth author Soto, Claudio author 2013-02 Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer’s disease. However, inconsistent results have been reported regarding the risk of Alzheimer’s disease among smokers. Previous studies in experimental animal models have reported that administration of some cigarette components (for example, nicotine) alters amyloid-b aggregation, providing a possible link. However, extrapolation of these findings towards the in vivo scenario is not straightforward as smoke inhalation involves a number of other components. Here, we analysed the effect of smoking under more relevant conditions. We exposed transgenic mouse models of Alzheimer’s disease to cigarette smoke and analysed the neuropathological alterations in comparison with animals not subjected to smoke inhalation. Our results showed that smoking increases the severity of some abnormalities typical of Alzheimer’s disease, including amyloidogenesis, neuroinflammation and tau phosphorylation. Our findings suggest that cigarette smoking may increase Alzheimer’s disease onset and exacerbate its features and thus, may constitute an important environmental risk factor for Alzheimer’s disease. Moreno-Gonzalez, I., Estrada, L., Sanchez-Mejias, E. et al. Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease. Nat Commun 4, 1495 (2013). https://hdl.handle.net/10630/34303 10.1038/ncomms2494 Alzheimer, Enfermedad Tabaco -- Consumo Enfermedades -- Modelos animales Amiloide Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease