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oai:riuma.uma.es:10630/344002026-02-03T11:36:18Zcom_10630_2254col_10630_37953

Pinto-Medel, María Jesús García-León, Juan Antonio Oliver-Martos, Begoña López-Gómez, Carlos Luque, Gloria Arnáiz-Urrutia, Carlos Órpez, Teresa Marín-Bañasco, Carmen Fernández Fernández, Óscar Leyva-Fernández, Laura 2024-10-07T08:49:37Z 2024-10-07T08:49:37Z 2012-01-18 Pinto-Medel MJ, García-León JA, Oliver-Martos B, López-Gómez C, Luque G, Arnáiz-Urrutia C, Orpez T, Marín-Bañasco C, Fernández O, Leyva L. The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis. J Neuroimmunol. 2012 Feb 29;243(1-2):1-11 https://hdl.handle.net/10630/34400 10.1016/j.jneuroim.2011.11.008 Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively with repeated stimulations, leading to the generation of CD28− T-cells. Our aim was to examine whether CD4+CD28- T cells were enriched in MS patients, and characterize the phenotype of this subset in MS patients and healthy controls (HC). All these changes could provide these CD4+CD28- T cell characteristics that might be involved in the pathogenesis of MS, turning this T-cell subset into a potential target for future therapeutic strategies. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Esclerosis múltiple Moleculas de adhesión celular Células T The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis. journal article