2026-05-30T09:53:10Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/344472026-02-03T11:09:03Zcom_10630_2254col_10630_37953

Stem Cell-Derived Oligodendroglial Cells for Therapy in Neurological Diseases. García-León, Juan Antonio Verfaillie, Catherine M. Esclerosis múltiple There are an important number of neurological diseases where not neurons but glia are the responsible cells for the degeneration of the nervous system. In the last years, determinant roles for oligodendrocytes (OLs) have been demonstrated not only in myelin generation and maintenance but also for metabolic support of neurons. Oligodendroglial defects lead to brain degeneration in several diseases, supporting the idea that not only endogenous regeneration but also administration of exogenous OL precursors will lead to overcome functional deficits. In this review, we discuss many diseases where OLs play a crucial role, and focus on the different sources and methods to obtain oligodendroglial cells that could be used in cell therapy for myelin-related and oligodendrocyte-deficient diseases. 2024-10-07T11:42:20Z 2024-10-07T11:42:20Z 2016-07 journal article García-León A. Juan, Verfaillie M. Catherine, Stem Cell-Derived Oligodendroglial Cells for Therapy in Neurological Diseases, Current Stem Cell Research & Therapy; Volume 11, Issue 7, Year 2016, . DOI: 10.2174/1574888X10666150902095312 https://hdl.handle.net/10630/34447 10.2174/1574888x10666150902095312 eng http://creativecommons.org/licenses/by-nc/4.0/ open access Atribución-NoComercial 4.0 Internacional Bentham Science