2026-05-31T00:11:00Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/345042026-02-03T11:03:30Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
García-León, Juan Antonio
author
Pinto-Medel, María-Jesús
author
García-Trujillo, Lucía
author
López-Gómez, Carlos
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Oliver-Martos, Begoña
author
Prat-Arrojo, Isidro
author
Marín-Bañasco, Carmen
author
Suardíaz-García, Margarita
author
Maldonado-Sánchez, Rafael
author
Fernández-Fernández, Óscar
author
Leyva-Fernández, Laura
2024-10-08T10:58:55Z
2024-10-08T10:58:55Z
2011-09
Juan A García-León, María J Pinto-Medel, Lucía García-Trujillo, Carlos López-Gómez, Begoña Oliver-Martos, Isidro Prat-Arrojo, Carmen Marín-Bañasco, Margarita Suardíaz-García, Rafael Maldonado-Sanchez, Oscar Fernández-Fernández, Laura Leyva-Fernández. Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients. Mol Immunol. 2011 Sep;48(15-16):1896-902. doi: 10.1016/j.molimm.2011.05.018. Epub 2011 Jun 12.
https://hdl.handle.net/10630/34504
10.1016/j.molimm.2011.05.018
Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to contribute to the pathogenesis of several autoimmune diseases, but their role in multiple sclerosis (MS) is still unclear. Here we determined the influence of KIR genes and their HLA class I ligands on susceptibility to MS and on the response to interferon-beta treatment in a Spanish population. KIR and HLA genotyping were performed in 200 MS patients and 200 controls. Significantly higher frequencies were found for KIR2DL5 and KIR3DS1 genes in MS patients and the carriage of the KIR2DL1 gene was associated with a higher progression index. Moreover, the frequency of the HLA-Bw4 motif was significantly reduced in MS patients. The KIR2DL1 and HLA-C2 matches were more frequent in MS patients, whereas the KIR3DL1 and HLA-Bw4 matches were more frequent in healthy controls. Nevertheless, non significant associations were found between all the KIR genes and therapeutic response to interferon-beta. Our results confirm that the carriage of HLA-Bw4 is a protective factor in MS and suggest that KIR2DL5 and KIR3DS1 may have a predisposing role in the disease.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Esclerosis múltiple
Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients.
journal article
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MIMM_3730 proofs corrected Juan.pdf