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Cheng-Sánchez, Iván García-Ruiz, Cristina Sarabia-García, Francisco Ramón 2024-10-14T11:36:10Z 2024-10-14T11:36:10Z 2016 Cheng-Sánchez, I.; García-Ruiz, C.; Sarabia, F. An olefin metathesis approach towards the solomonamides. Tetrahedron Lett. 2016, 57, 30, 3392-3395 https://doi.org/10.1016/j.tetlet.2016.06.081 https://hdl.handle.net/10630/34739 10.1016/j.tetlet.2016.06.081 A new synthetic strategy directed towards the solomonamides, a novel class of cyclopeptides of marine origin, has been developed utilizing an olefin metathesis reaction to form the [15]-membered ring contained in these natural products. We demonstrated the efficiency and validity of this synthetic approach for the construction of the macrocyclic core of the solomonamides in a minimally oxidized system. In fact, the olefin metathesis cyclization proceeded in a stereoselective manner to provide exclusively the Z-isomer in high yield. The described synthetic strategy for the solomonamides allows for access to the natural products, as well as offering the opportunity for the generation of a diverse set of analogues in the subsequent oxidation phase eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Química clínica An olefin metathesis approach towards the solomonamides. journal article