2026-06-06T17:09:52Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/348292026-02-03T11:40:54Zcom_10630_2254col_10630_37956
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Pacheco-Torres, Jesús
author
Moreno, Andrea
author
Fernández, Begoña
author
Pérez-Cervera, Laura
author
Caramés-Tejedor, José María
author
Fernández-Mollá, Luis Miguel
author
Pérez-Montoyo, Elena
author
Martínez-Sánchez, Miriam
author
Moratal, David
author
Canals-Gamoneda, Santiago
editor
Manahan-Vaughan, Denise
2024-10-21T08:36:05Z
2024-10-21T08:36:05Z
2018
https://hdl.handle.net/10630/34829
10.1016/B978-0-12-812028-6.00024-0
Since its discovery in the early 1990s, blood oxygen level dependent signal-based functional magnetic resonance imaging (fMRI) has become a fundamental technique for the study of brain activity in basic and clinical research. Functional MRI provides an indirect but robust and quantitative readout of brain activity through the tight coupling between cerebral blood flow and neuronal activation, the so-called neurovascular coupling. Combined with experimental techniques such as electrophysiology, intracerebral microstimulation, optogenetics, or pharmacogenetics, it provides a powerful framework to investigate the impact of specific circuit manipulations on overall brain dynamics. In this chapter we review the contribution of some of these techniques to the understanding of short- and long-term plasticity processes and provide a comprehensive account of the protocols used in our laboratory. Considerations on the interpretation of the results and the limitations of the approach are also discussed.
eng
Resonancia magnética nuclear (Medicina) - Modelos animales
Functional MRI of Synaptic Plasticity.
book part
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URL
https://riuma.uma.es/bitstreams/339cbe97-636b-4f4e-8553-d97fa891b6ea/download
File
MD5
49c613dd840f45511629447614960124
529699
application/pdf
2018 MRI synaptic plasticity.pdf