2026-06-07T05:53:20Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/348732026-02-03T11:02:56Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Blasco, Telmo author Pérez-Burillo, Sergio author Balzerani, Francesco author Hinojosa Nogueira, Daniel author Lerma Aguilera, Alberto author Pastoriza, Silvia author Cendoya, Xabier author Rubio, Ángel author Gosalbes, María José author Jiménez Hernández, Nuria author Francino, María Pilar author Apaolaza, Íñigo author Rufián-Henares, José Ángel author Planes, Francisco Javier author 2021-08-05 Understanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to systematically address this complex problem. However, when applied to nutritional questions, a major issue in existing reconstructions is the limited information about compounds in the diet that are metabolized by the gut microbiota. Here, we present AGREDA, an extended reconstruction of diet metabolism in the human gut microbiota. AGREDA adds the degradation pathways of 209 compounds present in the human diet, mainly phenolic compounds, a family of metabolites highly relevant for human health and nutrition. We show that AGREDA outperforms existing reconstructions in predicting diet-specific output metabolites from the gut microbiota. Using 16S rRNA gene sequencing data of faecal samples from Spanish children representing different clinical conditions, we illustrate the potential of AGREDA to establish relevant metabolic interactions between diet and gut microbiota. Blasco, T., Pérez-Burillo, S., Balzerani, F. et al. An extended reconstruction of human gut microbiota metabolism of dietary compounds. Nat Commun 12, 4728 (2021). [https://doi.org/10.1038/s41467-021-25056-x] https://hdl.handle.net/10630/34873 10.1038/s41467-021-25056-x Intestinos - Microbiología Aparato digestivo - Metabolismo Biología computacional An extended reconstruction of human gut microbiota metabolism of dietary compounds.