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00925njm 22002777a 4500 dc Martín-Gálvez, Francisca author García-Ruiz, Cristina author Sánchez-Ruiz, Antonio author Valeriote, Frederick A. author Sarabia-García, Francisco Ramón author 2013-03-19 Based on our previously described synthetic strategy for bengamide E, a natural product of marine origin with antitumor activity, a small library of analogues modified at the terminal olefinic position was generated with the objective of investigating the effect of structural modifications on antitumor properties. Biological evaluation of these analogues, consisting of IC50 determinations against various tumor cell lines, revealed important aspects with respect to the structural requirements of this olefinic position for activity. Interestingly, the analogue possessing a cyclopentyl group displayed greater potency than the parent bengamide E, representing a key finding upon which to base further investigations into the design of new analogues with promising biological activities. F. Martín-Gálvez, C. García-Ruiz, A. Sánchez-Ruiz, F. A. Valeriote, F. Sarabia An array of bengamide E analogues modified at the terminal olefinic position: synthesis and antitumor properties. ChemMedChem 2023, 8(5), 819-831. https://doi.org/10.1002/cmdc.201300033 https://hdl.handle.net/10630/35017 10.1002/cmdc.201300033 Síntesis asimétrica Síntesis orgánica Antineoplásicos An array of bengamide E analogues modified at the terminal olefinic position: Synthesis and antimor properties.