2026-05-27T05:23:27Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/357062026-02-03T11:04:25Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc López-Márquez, Diego author Del Espino Pérez, Ángel author Ruiz-Albert, Francisco Javier author Rodríguez-Bejarano, Eduardo author Brodersen, Peter author Beuzón-López, Carmen del Rosario author 2023-10-13 Plants use different receptors to detect potential pathogens: membrane-anchored pattern recognition receptors (PRRs) activated upon perception of pathogen-associated molecular patterns (PAMPs) that elicit pattern-triggered immunity (PTI); and intracellular nucleotide-binding leucine-rich repeat proteins (NLRs) activated by detection of pathogen-derived effectors, activating effector-triggered immunity (ETI). The interconnections between PTI and ETI responses have been increasingly reported. Elevated NLR levels may cause autoimmunity, with symptoms ranging from fitness cost to developmental arrest, sometimes combined with run-away cell death, making accurate control of NLR dosage key for plant survival. Small RNA-mediated gene regulation has emerged as a major mechanism of control of NLR dosage. Twenty-two nucleotide miRNAs with the unique ability to trigger secondary siRNA production from target transcripts are particularly prevalent in NLR regulation. They enhance repression of the primary NLR target, but also bring about repression of NLRs only complementary to secondary siRNAs. We summarize current knowledge on miRNAs and siRNAs in the regulation of NLR expression with an emphasis on 22 nt miRNAs and propose that miRNA and siRNA regulation of NLR levels provides additional links between PTI and NLR defense pathways to increase plant responsiveness against a broad spectrum of pathogens and control an efficient deployment of defenses López-Márquez D, Del-Espino Á, Ruiz-Albert J, Bejarano ER, Brodersen P, Beuzón CR. Regulation of plant immunity via small RNA-mediated control of NLR expression. J Exp Bot. 2023 Oct 13;74(19):6052-6068 https://hdl.handle.net/10630/35706 10.1093/jxb/erad268 Plantas - Resistencia a plagas y enfermedades Regulation of plant immunity via small RNA-mediated control of NLR expression