2026-05-31T00:06:38Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/360232026-02-03T10:49:42Zcom_10630_2254col_10630_37953

Fundamental limit of detection of photonic biosensors with coherent phase read-out Molina-Fernández, Íñigo Leuermann, Jonas Ortega-Moñux, Alejandro Wanguemert-Pérez, Juan Gonzalo Halir, Robert Detectores Photonic biosensors offer label-free detection of biomolecules for applications rangingfromclinicaldiagnosistofoodqualitymonitoring. BothsensorsbasedonMach-Zehnder interferometers and ring resonators are widely used, but are usually read-out using different schemes, making a direct comparison of their fundamental limit of detection challenging. A coherent detection scheme, adapted from optical communication systems, has been recently showntoachieveexcellentdetectionlimits,usingasimplefixed-wavelengthsource. Herewe present, for the first time, a theoretical model to determine the fundamental limit of detection of suchacoherentread-outsystem,forbothinterferometricandresonantsensors. Basedonthis analysis,weprovideguidelinesforsensoroptimizationinthepresenceofopticallossesandshow thatinterferometricsensorsarepreferableoverresonantstructureswhenthesensorsizeisnot limited bythe available samplevolume. 2025-01-09T08:24:33Z 2025-01-09T08:24:33Z 2025-01-09T08:24:33Z 2019-04-01 journal article Íñigo Molina-Fernández, Jonas Leuermann, Alejandro Ortega-Moñux, J. Gonzalo Wangüemert-Pérez, and Robert Halir, "Fundamental limit of detection of photonic biosensors with coherent phase read-out," Opt. Express 27, 12616-12629 (2019) https://hdl.handle.net/10630/36023 10.1364/OE.27.012616 eng open access Optica Publishing Group