2026-05-27T05:24:14Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/361052026-02-03T11:23:46Zcom_10630_2254col_10630_37953

Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker Molina, Noemí Nájera-Albendín, Francisco Guadix-Domínguez, Juan Antonio perez-pomarez, Jose M Vida-Pol, Yolanda Perez-Inestrosa, Ezequiel Marcadores bioquímicos Herein, we present an easy and efficient synthesis of amino terminal dendrons, combining protection/deprotection reactions with copper-catalyzed azide alkyne cycloaddition in a convergent way. This new approach affords dendrons in gram scale with excellent yields and easy purification. By choosing the appropriate azido-functionalized core, these dendrons lead to a more efficient and controlled convergent synthesis of dendrimers with different sizes and shapes and multivalence. The amino terminal dendrimers were analyzed by diffusion-ordered spectroscopy experiments. The observed dendrimer size is in excellent correlation with the expected size and shape by molecular dynamic simulations. The construction of these kinds of nanostructures, in a simple and efficient way, opens new opportunities for biomedical applications. Moreover, by choosing the appropriate core, these versatile macromolecules become an excellent fluorescent biomarker. 2025-01-10T08:27:34Z 2025-01-10T08:27:34Z 2025-01-10T08:27:34Z 2019 journal article Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker Noemi Molina, Francisco Nájera, Juan A. Guadix, Jose M. Perez-Pomares, Yolanda Vida and Ezequiel Perez-Inestrosa Journal of Organic Chemistry, 2019, 84 (16), 10197-10208. DOI: 10.1021/acs.joc.9b01369 https://hdl.handle.net/10630/36105 10.1021/acs.joc.9b01369 eng open access ACS Publications