2026-05-27T12:12:38Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/361932026-02-03T11:09:39Zcom_10630_2254col_10630_37953

Du, Xiaoyong Cheng-Sánchez, Iván Nevado, Cristina 2025-01-13T11:17:06Z 2025-01-13T11:17:06Z 2023-05-30 https://hdl.handle.net/10630/36193 https://doi.org/10.1021/jacs.3c00744 An asymmetric three-component carbosulfonylation of alkenes is presented here. The reaction, involving the simultaneous formation of a C–C and a C–S bond across the π-system, uses a dual nickel/photoredox catalytic system to produce both β-aryl and β-alkenyl sulfones in high yields and with excellent levels of stereocontrol (up to 99:1 er). This protocol exhibits a broad substrate scope and excellent functional group tolerance and its synthetic potential has been demonstrated by successful applications toward pharmacologically relevant molecules. A broad array of control experiments supports the involvement of a secondary alkyl radical intermediate generated through radical addition of a sulfonyl radical to the double bond. Moreover, stoichiometric and cross-over experiments further suggest an underlying Ni(0)/Ni(I)/Ni(III) pathway operative in these transformations. eng open access Níquel Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes journal article