2026-05-31T15:17:31Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/362012026-02-03T11:23:36Zcom_10630_2254col_10630_37953

Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with Alkenyl Bromides Hu, Xia Cheng-Sánchez, Iván Cuesta-Galisteo, Sergio Nevado, Cristina Níquel An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl homoallylic amines with excellent E-selectivity. This electroreductive strategy proceeds in the absence of heterogeneous metal reductants and sacrificial anodes by employing constant current electrolysis in an undivided cell with triethylamine as a terminal reductant. The reaction features mild conditions, remarkable stereocontrol, broad substrate scope, and excellent functional group compatibility, which was illustrated by the late-stage functionalization of bioactive molecules. Mechanistic studies indicate that this transformation conforms with a stereoconvergent mechanism in which the aziridine is activated through a nucleophilic halide ring-opening process. 2025-01-13T11:30:14Z 2025-01-13T11:30:14Z 2025-01-13T11:30:14Z 2023-03-07 journal article https://hdl.handle.net/10630/36201 https://doi.org/10.1021/jacs.2c12869 eng open access ACS