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00925njm 22002777a 4500 dc Baglietto-Vargas, David author López-Téllez, Juan Félix author Moreno-González, Inés author Gutiérrez-Pérez, Antonia author Aledo-Ramos, Juan Carlos author 2004-01-31 Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in β-cells is still unresolved. We have found that the endocrine pancreas co-expresses two isoforms of GA (glutaminase), denoted as kidney-type (KGA) and liver-type (LGA), with a complementary cellular pattern of expression. Whereas KGA was mainly present in α-cells, LGA was very abundant in β-cells. This spatial segregation may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells. Baglietto-Vargas D, López-Téllez JF, Moreno-González I, Gutiérrez A, Aledo JC. Segregation of two glutaminase isoforms in islets of Langerhans. Biochem J. 2004 Jul 15;381(Pt 2):483-7. doi: 10.1042/BJ20040523. PMID: 15089745; PMCID: PMC1133855. https://hdl.handle.net/10630/36525 10.1042/BJ20040523 Ácido glutámico Segregation of two glutaminase isoforms in islets of Langerhans.