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oai:riuma.uma.es:10630/365252026-03-13T07:55:48Zcom_10630_2254col_10630_37953

Baglietto-Vargas, David López-Téllez, Juan Félix Moreno-González, Inés Gutiérrez-Pérez, Antonia Aledo-Ramos, Juan Carlos 2025-01-20T07:59:47Z 2025-01-20T07:59:47Z 2004-01-31 Baglietto-Vargas D, López-Téllez JF, Moreno-González I, Gutiérrez A, Aledo JC. Segregation of two glutaminase isoforms in islets of Langerhans. Biochem J. 2004 Jul 15;381(Pt 2):483-7. doi: 10.1042/BJ20040523. PMID: 15089745; PMCID: PMC1133855. https://hdl.handle.net/10630/36525 10.1042/BJ20040523 Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in β-cells is still unresolved. We have found that the endocrine pancreas co-expresses two isoforms of GA (glutaminase), denoted as kidney-type (KGA) and liver-type (LGA), with a complementary cellular pattern of expression. Whereas KGA was mainly present in α-cells, LGA was very abundant in β-cells. This spatial segregation may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Ácido glutámico Segregation of two glutaminase isoforms in islets of Langerhans. journal article