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oai:riuma.uma.es:10630/365302026-03-13T07:39:48Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Gavilán, M. Paz author Revilla, Elisa author Pintado, Cristina author Castaño, Angélica author Vizuete, María Luisa author Moreno-González, Inés author Baglietto-Vargas, David author Sánchez-Varo, Raquel María author Vitorica Ferrández, Javier author Gutiérrez-Pérez, Antonia author Ruano, Diego author 2007-06-29 Increased neuroinflammatory reaction is frequently observed during normal brain aging. However, a direct link between neuroinflammation and neurodegeneration during aging has not yet been clearly shown. Here, we have characterized the agerelated hippocampal inflammatory processes and the potential relation with hippocampal neurodegeneration. The mRNA expression of the pro-inflammatory cytokines IL-1b and tumor necrosis factor-a (TNF-a), and the iNOs enzyme was significantly increased in aged hippocampus. Accordingly, numerous activated microglial cells were observed in aged rats. These cells were differentially distributed along the hippocampus, being more frequently located in the hilus and the CA3 area. The mRNA expression of somatostatin, a neuropeptide expressed by some GABAergic interneurons, and the number of somatostatin-immunopositive cells decreased in aged rats. However, the number of hippocampal parvalbumin-containing GABAergic interneurons was preserved. Interestingly, in aged rats, the mRNA expression of somatostatin and IL-1b was inversely correlated and, the decrease in the number of somatostatinimmunopositive cells was higher in the hilus of dentate gyrus than in the CA1 region. Finally, intraperitoneal chronic lipopolysaccharide (LPS) injection in young animals mimicked the agerelated hippocampal inflammation as well as the decrease of somatostatin mRNA expression. Present results strongly support the neuroinflammation as a potential factor involved in the age-related degeneration of somatostatin GABAergic cells. Gavilán MP, Revilla E, Pintado C, Castaño A, Vizuete ML, Moreno-González I, Baglietto-Vargas D, Sánchez-Varo R, Vitorica J, Gutiérrez A, Ruano D. Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons. J Neurochem. 2007 Nov;103(3):984-96. doi: 10.1111/j.1471-4159.2007.04787.x. Epub 2007 Jul 31. PMID: 17666053. https://hdl.handle.net/10630/36530 10.1111/j.1471-4159.2007.04787.x Sistema nervioso - Degeneración Neuroglia Sistema nervioso - Inflamación Envejecimiento Hipocampo (Cerebro) Somatostatina Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.