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oai:riuma.uma.es:10630/365782026-02-03T11:23:35Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Vidal-Valenzuela, Isabel author Fernández-Florido, Elena author Marrero-Capitán, Ana Dácil author Castilla-Ruiz, Laura author Rodríguez-Quesada, Ana María author Martínez-Póveda, Beatriz Amparo author Medina-Torres, Miguel Ángel author 2022 The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate as an anti-angiogenic compound by using cultured endothelial cells and several in vitro assays that simulate key steps of the angiogenic process, including endothelial cell proliferation, migration, invasion, and tube formation. Our results show that dimethyl itaconate interferes with all the previously mentioned steps of the angiogenic process, suggesting that dimethyl itaconate behaves as an anti-angiogenic compound. Vidal, I.; Fernández-Florido, E.; Marrero, A.D.; Castilla, L.; R. Quesada, A.; Martínez-Poveda, B.; Medina, M.Á. The Immunomodulator Dimethyl Itaconate Inhibits Several Key Steps of Angiogenesis in Cultured Endothelial Cells. Int. J. Mol. Sci. 2022, 23, 15972. https://doi.org/10.3390/ ijms232415972 https://hdl.handle.net/10630/36578 https://doi.org/10.3390/ijms232415972 Neovascularización Inmunomoduladores The immunomodulator dimethyl itaconate inhibits several key steps of angiogenesis in cultured endothelial cells