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oai:riuma.uma.es:10630/365782026-02-03T11:23:35Zcom_10630_2254col_10630_37953

The immunomodulator dimethyl itaconate inhibits several key steps of angiogenesis in cultured endothelial cells Vidal-Valenzuela, Isabel Fernández-Florido, Elena Marrero-Capitán, Ana Dácil Castilla-Ruiz, Laura Rodríguez-Quesada, Ana María Martínez-Póveda, Beatriz Amparo Medina-Torres, Miguel Ángel Neovascularización Inmunomoduladores The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate as an anti-angiogenic compound by using cultured endothelial cells and several in vitro assays that simulate key steps of the angiogenic process, including endothelial cell proliferation, migration, invasion, and tube formation. Our results show that dimethyl itaconate interferes with all the previously mentioned steps of the angiogenic process, suggesting that dimethyl itaconate behaves as an anti-angiogenic compound. 2025-01-20T12:58:08Z 2025-01-20T12:58:08Z 2025-01-20T12:58:08Z 2022 journal article Vidal, I.; Fernández-Florido, E.; Marrero, A.D.; Castilla, L.; R. Quesada, A.; Martínez-Poveda, B.; Medina, M.Á. The Immunomodulator Dimethyl Itaconate Inhibits Several Key Steps of Angiogenesis in Cultured Endothelial Cells. Int. J. Mol. Sci. 2022, 23, 15972. https://doi.org/10.3390/ ijms232415972 https://hdl.handle.net/10630/36578 https://doi.org/10.3390/ijms232415972 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI