2026-06-05T17:26:52Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/365832026-02-03T11:29:59Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Fernández-Santamaría, Rubén author Salas, Maria author Ariza Veguillas, Adriana author Jiménez, María A. author González-Mendiola, María R. author Sánchez, María L. author Boteanu, Cosmin author Mayorga Mayorga, Cristobalina author Fernández-Duarte, Tahía Diana author Torres, María José author Laguna, José J. author 2024-11-27 Omeprazole is a widely prescribed proton pump inhibitor [1], with 1%–3% of adverse reactions being reported. Up to 86% of these reactions are IgE mediated [2] and half of them anaphylaxis [1]. An accurate diagnosis is essential, with skin testing (STs) showing high specificity and positive predictive value (PPV) (100%), but lower sensitivity (60%) and negative predictive value (NPV) (70%–90%) [2]. As stated in a recent position paper of the European Academy of Allergy and Clinical Immunology (EAACI), the basophil activation test (BAT) is a reliable option in the diagnosis of immediate hypersensitivity to proton pump inhibitors [3]. In fact, previous research from our group reported that BAT has a higher sensitivity than STs (73.8%) and similar specificity, PPV (100%) and NPV (66.7%) [1]. Interestingly, the combination of STs and BAT can increase sensitivity up to 85.7%, being BAT positive in 57.1% of patients with negative STs [1]. Fernandez-Santamaria, R., Salas, M., Ariza, A., Jiménez, M.A., González-Mendiola, M.R., Sanchez, M.L., Boteanu, C., Mayorga, C., Fernandez, T.D., Torres, M.J. and Laguna, J.J. (2025), Basophil Activation Test Positivity Decreases With Time in Immediate Allergic Reactions to Proton Pump Inhibitors. Allergy. https://doi.org/10.1111/all.16406 https://hdl.handle.net/10630/36583 10.1111/all.16406 Anafilaxia Basophil activation test positivity decreases with time in immediate allergic reactions to proton pump inhibitors