2026-05-29T23:03:50Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/367822026-02-03T11:13:40Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Díez-Ricote, Laura author San-Cristobal, Rodrigo author Consejo, M Jose author Martínez González, Miguel Ángel author Corella, Dolores author Salas-Salvadó, Jordi author Goday, Albert author Martínez, J Alfredo author Alonso Gómez, Ángel M author Warnberg, Julia author Vioqué, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramón author Tinahones-Madueño, Francisco José author Lapetra, José author Serra-Majem, Lluís author Bueno-Cavanillas, Aurora author Tur, Josep A author Martín-Sánchez, Vicente author Pintó, Xavier author Gaforio, José J author Matía-Martín, Pilar author Vidal, Josep author Mas Fontao, Sebastián author Ros, Emilio author Vázquez-Ruiz, Zenaida author Ortega-Azorín, Carolina author García-Gavilán, Jesús F author Malcampo, Mireia author Martínez-Urbistondo, Diego author Tojal-Sierra, Lucas author García-Rodríguez, Antonio author Gómez-Belvert, Nuria author Chaplin, Alice author García-Rios, Antonio author Bernañ-López, Rosa M author Santos-Lozano, José M author Basterra-Gortari, Javier author Sorli, José V author Murphy, Michelle author Gasulla, Griselda author Micó, Victor author Salaverria-Lete, Itziar author Goñi Ochandorena, Estibaliz author Babio, Nancy author Herraiz, Xavier author Ordovás, José M author Daimiel, Lidia author 2022 Background: Choline and betaine intakes have been related to cardiovascular health. Objectives: We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial. Methods: We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMEDPlus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. Results: The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (−3.39 and −2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (−0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (−2.93 and −2.78 kg, respectively), BMI (−1.05 and −0.99, respectively), waist circumference (−3.37 and −3.26 cm, respectively), total cholesterol (−4.74 and −4.52 mg/dL, respectively), and LDL cholesterol (−4.30 and −4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (−5.42 and −5.74 mg/dL, respectively). Conclusions: Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation. This trial was registered at https://www.isrctn.com/ as ISRCTN89898870. Am J Clin Nutr 2022;116:1565–1579. Laura Díez-Ricote... [et al.]. One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial, The American Journal of Clinical Nutrition, Volume 116, Issue 6, December 2022, Pages 1565–1579, [https://doi.org/10.1093/ajcn/nqac255] https://hdl.handle.net/10630/36782 10.1093/ajcn/nqac255 Aparato circulatorio Dietética One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial.