2026-05-30T12:24:49Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/367822026-02-03T11:13:40Zcom_10630_2254col_10630_37953

One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial. Díez-Ricote, Laura San-Cristobal, Rodrigo Consejo, M Jose Martínez González, Miguel Ángel Corella, Dolores Salas-Salvadó, Jordi Goday, Albert Martínez, J Alfredo Alonso Gómez, Ángel M Warnberg, Julia Vioqué, Jesús Romaguera, Dora López-Miranda, José Estruch, Ramón Tinahones-Madueño, Francisco José Lapetra, José Serra-Majem, Lluís Bueno-Cavanillas, Aurora Tur, Josep A Martín-Sánchez, Vicente Pintó, Xavier Gaforio, José J Matía-Martín, Pilar Vidal, Josep Mas Fontao, Sebastián Ros, Emilio Vázquez-Ruiz, Zenaida Ortega-Azorín, Carolina García-Gavilán, Jesús F Malcampo, Mireia Martínez-Urbistondo, Diego Tojal-Sierra, Lucas García-Rodríguez, Antonio Gómez-Belvert, Nuria Chaplin, Alice García-Rios, Antonio Bernañ-López, Rosa M Santos-Lozano, José M Basterra-Gortari, Javier Sorli, José V Murphy, Michelle Gasulla, Griselda Micó, Victor Salaverria-Lete, Itziar Goñi Ochandorena, Estibaliz Babio, Nancy Herraiz, Xavier Ordovás, José M Daimiel, Lidia Aparato circulatorio Dietética Background: Choline and betaine intakes have been related to cardiovascular health. Objectives: We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial. Methods: We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMEDPlus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. Results: The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (−3.39 and −2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (−0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (−2.93 and −2.78 kg, respectively), BMI (−1.05 and −0.99, respectively), waist circumference (−3.37 and −3.26 cm, respectively), total cholesterol (−4.74 and −4.52 mg/dL, respectively), and LDL cholesterol (−4.30 and −4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (−5.42 and −5.74 mg/dL, respectively). Conclusions: Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation. This trial was registered at https://www.isrctn.com/ as ISRCTN89898870. Am J Clin Nutr 2022;116:1565–1579. 2025-01-23T07:36:52Z 2025-01-23T07:36:52Z 2025-01-23T07:36:52Z 2022 journal article Laura Díez-Ricote... [et al.]. One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial, The American Journal of Clinical Nutrition, Volume 116, Issue 6, December 2022, Pages 1565–1579, [https://doi.org/10.1093/ajcn/nqac255] https://hdl.handle.net/10630/36782 10.1093/ajcn/nqac255 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Oxford University Press