2026-05-27T05:32:53Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/367882026-02-03T11:04:29Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Mates-Sánchez, José Manuel
author
Campos-Sandoval, José Ángel
author
De los Santos-Jiménez, Juan
author
Márquez-Gómez, Javier
2025-01-23T08:46:08Z
2025-01-23T08:46:08Z
2019
Dysregulation of glutaminase and glutamine synthetase in cancer. Matés JM, Campos-Sandoval JA, Santos-Jiménez JL, Márquez J. Cancer Lett. 2019 Dec 28;467:29-39. doi: 10.1016/j.canlet.2019.09.011. Epub 2019 Sep 28. PMID: 31574293
https://hdl.handle.net/10630/36788
10.1016/j.canlet.2019.09.011
Besides fast glucose catabolism, many types of cancers are characterized by elevated glutamine consumption. Medical oncology pursuits to block specific pathways, mainly glycolysis and glutaminolysis, in tumor cells to arrest cancer development. This strategy frequently induces adaptive metabolic resistance that must be countered. Combination therapy is an anticancer synergistic tool to overcome both cancer growth and resistance mechanisms. Dysregulation of glutaminase and glutamine synthetase are key events that allow anabolic adaptation of tumors. Several specific drugs that inhibit metabolic enzymes dealing with glutamine metabolism have been able to eliminate some neoplasms. Targeting the tumor microenvironment can be also another essential factor to be taken into account when single or combined cancer metabolic therapy fails.
eng
Cáncer - Aspectos moleculares
Dysregulation of glutaminase and glutamine synthetase in cancer.
journal article
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350c6277ae9d6f7dfd417dd8ca356f1e
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Acepted version Cancer Lett 2019.pdf