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Expression of the Antiapoptotic Proteins Clusterin and Bcl-2 in Laryngeal Squamous Cell Carcinomas Redondo-Bautista, Maximino Esteban, Francisco González-Moles, Miguel A. Delgado-Rodríguez, Miguel Nevado, Manuel Torres-Muñoz, Jorge E. Téllez-Santana, Teresa Villar, Eduardo Morell Ocaña, Miguel Petito, Carol K. Glucoproteínas Laringe - Cáncer https://openpolicyfinder.jisc.ac.uk/id/publication/13040 Bcl-2 and clusterin genes have been related to the inhibition of apoptosis, an event that plays a key role in malignant transformation and in invasive disease. In this work, we determine the significance of clusterin and bcl-2 expression in a large series of laryngeal carcinomas. We used immunohistochemical methods and in situ hybridization to examine the expression of these proteins. Nontumoral epithelial laryngeal tissues did not express clusterin and bcl-2 proteins. However, 9% (14 out of 154) and 25% of these tumors (39 of 154) had positive clusterin and bcl-2 staining, respectively. Clusterin expression was significantly related to the degree of local invasion and higher bcl-2 expression was found in these clusterin-positive tumors (p < 0.05). Bcl-2 expression was significantly correlated with supraglottic localization, nodal metastases, invasion in depth, and poorly differentiated tumors. However, by multivariate analysis, bcl-2 was shown to be an independent predictor of good prognosis in these tumors (OR = 0.12, 95% CI = 0.02-0.91). These findings indicate that clusterin and bcl-2 are upregulated in laryngeal carcinomas and their expression is related to the invasiveness of these tumors. 2025-01-23T10:27:08Z 2025-01-23T10:27:08Z 2006 journal article Redondo M, Esteban F, González-Moles MA, Delgado-Rodríguez M, Nevado M, Torres-Muñoz JE, Tellez T, Villar E, Morell M, Petito CK. Expression of the antiapoptotic proteins clusterin and bcl-2 in laryngeal squamous cell carcinomas. Tumour Biol. 2006;27(4):195-200. doi: 10.1159/000093055. Epub 2006 May 2. PMID: 16675913. https://hdl.handle.net/10630/36808 10.1159/000093055 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Karger