2026-05-30T05:15:09Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/368962026-02-03T11:08:53Zcom_10630_2254col_10630_37953

Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis. Rodríguez González Cortes, Arthur Sánchez-Siles, Juan Manuel Ackerman, Jerome L González-Quevedo, David Garcia, Angel Yaghoubi, Farid Abdallah, Mohamed-Nur Eimar, Hazem Alsheghri, Ammar Laurenti, Marco Guerado-Parra, Enrique García-de-Quevedo-Puerta, David Tamimi, Faleh Tomografía Imágenes por resonancia magnética Fémures - fracturas Crystal Femoral head bone fractures Hydroxyapatite Micro-computed tomography Nuclear magnetic resonance Osteoporosis Structure https://openpolicyfinder.jisc.ac.uk/id/publication/16737 Purpose: The aim of this study was to analyze trabecular bone architecture, and its crystal and organic composition in humans, by comparing samples taken from patients who had a hip fracture (HF) and individuals with hip osteoarthritis (HOA). Methods: The study included 31 HF patients and 42 cases of HOA who underwent joint replacement surgery between 1/1/2013 and 31/12/2013. Trabecular bone samples were collected from the femoral heads and analyzed using a dual-energy X-ray absorptiometry, micro-CT, and solid-state high-resolution magic-angle-spinning nuclear magnetic resonance (MAS-NMR) spectroscopy. Results: No differences in proton or phosphorus concentration were found between the two groups using 1H single pulse, 31P single pulse, 31P single pulse with proton decoupling NMR spectroscopy, in hydroxyapatite (HA) c-axis or a-axis crystal length. Bone volume fraction (BV/TV), trabecular number (Tb.N), and bone mineral density (BMD) were higher in the HO group than in the HF group [28.6% ± 10.5 vs 20.3% ± 6.6 (p = 0.026); 2.58 mm-1 ± 1.57 vs 1.5 mm-1 ± 0.79 (p = 0.005); and 0.39 g/cm2 ± 0.10 vs. 0.28 g/cm2 ± 0.05 (p = 0.002), respectively]. The trabecular separation (Tp.Sp) was lower in the HO group 0.42 mm ± 0.23 compared with the HF group 0.58 mm ± 0.27 (p = 0.036). In the HO group, BMD was correlated with BV/TV (r = 0.704, p < 0.001), BMC (r = 0.853, p < 0.001), Tb.N (r = 0.653, p < 0.001), Tb.Sp (-0.561, p < 0.001) and 1H concentration (-0.580, p < 0.001) in the HO group. BMD was not correlated with BV/TV, Tb.Sp, Tb.Th, Tb.N, Tb.PF, 1H concentration or HA crystal size in the HF group. Conclusions: Patients with HO who did not sustain previous hip fractures had a higher femoral head BMD, BV/TV, and Tb.N than HF patients. In HO patients, BMD was positively correlated with the BV/TV and Tb.N and negatively correlated with the femoral head organic content and trabecular separation. 2025-01-24T10:08:31Z 2025-01-24T10:08:31Z 2020-08-12 journal article AM Tamimi I, Cortes ARG, Sánchez-Siles JM, Ackerman JL, González-Quevedo D, García Á, Yaghoubi F, Abdallah MN, Eimar H, Alsheghri A, Laurenti M, Al-Subaei A, Guerado E, García-de-Quevedo D, Tamimi F. Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis. Bone. 2020 Nov;140:115558. doi: 10.1016/j.bone.2020.115558. Epub 2020 Jul 27. PMID: 32730941. https://hdl.handle.net/10630/36896 10.1016/j.bone.2020.115558 eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf Elsevier