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oai:riuma.uma.es:10630/370202026-02-03T11:05:53Zcom_10630_2254col_10630_37953

Matesanz, Fuencisla Fernández-Fernández, Óscar Milne, Roger L. Fedetz, María Leyva-Fernández, Laura Guerrero, Miguel Delgado, Concepción Lucas, Miguel Izquierdo, Guillermo Alcina, Antonio 2025-01-27T08:44:58Z 2025-01-27T08:44:58Z 2008 Matesanz F, Fernández O, Milne RL, Fedetz M, Leyva L, Guerrero M, Delgado C, Lucas M, Izquierdo G, Alcina A. The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis. J Neuroimmunol 2008 Mar;195(1-2):146-50. Epub 2008 Mar 3. PMID: 18313765 https://hdl.handle.net/10630/37020 10.1016/j.jneuroim.2008.01.004 Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case–control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r2=0.87), differed between MS cases and controls. The C allele of FCRL3_3 was found to be protective for MS (per allele OR=0.81, 95% C.I.=0.70–0.94; P-value=0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Esclerosis múltiple The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis. journal article