2026-06-07T04:32:48Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/370202026-02-03T11:05:53Zcom_10630_2254col_10630_37953

The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis. Matesanz, Fuencisla Fernández-Fernández, Óscar Milne, Roger L. Fedetz, María Leyva-Fernández, Laura Guerrero, Miguel Delgado, Concepción Lucas, Miguel Izquierdo, Guillermo Alcina, Antonio Esclerosis múltiple Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case–control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r2=0.87), differed between MS cases and controls. The C allele of FCRL3_3 was found to be protective for MS (per allele OR=0.81, 95% C.I.=0.70–0.94; P-value=0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3. 2025-01-27T08:44:58Z 2025-01-27T08:44:58Z 2025-01-27T08:44:58Z 2008 journal article Matesanz F, Fernández O, Milne RL, Fedetz M, Leyva L, Guerrero M, Delgado C, Lucas M, Izquierdo G, Alcina A. The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis. J Neuroimmunol 2008 Mar;195(1-2):146-50. Epub 2008 Mar 3. PMID: 18313765 https://hdl.handle.net/10630/37020 10.1016/j.jneuroim.2008.01.004 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier