2026-05-31T19:39:51Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/371862026-02-03T11:21:37Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Martín-Sierra, Carmen author Bravo-Romero, María José author Saez, Maria Eugenia author De Rojas, Itziar author Santos, Marta author Martín-Carmona, Jesica author Corma-Gómez, Anaïs author González-Serna, Alejandro author Royo-Sánchez-Palencia, José Luis author Pineda, Juan A. author Rivero, Antonio author Rivero-Juárez, Antonio author Macías, Juan author Real-Navarrete, Luis Miguel author 2024 Background & aims It has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/HLA-C1 and KIR3DL1/≥2HLA-Bw4, are strongly associated with the lack of active infection and seroconversion after exposition to hepatitis C virus (HCV). Objective To determine whether these KIR-HLA combinations are relevant factors involved in that phenotype. Patients and methods In this retrospective case-control study, genotype data from a genome-wide association study previously performed on low susceptibility to HCV-infection carried out on 27 high-risk HCV-seronegative (HRSN) individuals and 743 chronically infected (CI) subjects were used. HLA alleles were imputed using R package HIBAG v1.2223 and KIR genotypes were imputed using the online resource KIR*IMP v1.2.0. Results It was possible to successfully impute at least one KIR-HLA genotype combination previously associated with the lack of infection and seroconversion after exposition to HCV in a total of 23 (85.2%) HRSN individuals and in 650 (87.5%) CI subjects. No KIR-HLA genotype combination analyzed was related to the HRSN condition. Conclusions Our results suggest that those KIR-HLA genotype combinations are not relevant factors involved in the lack of infection and seroconversion after exposition to HCV. More studies will be needed to completely understand this phenotype. Carmen Martín-Sierra, María José Bravo, María Eugenia Sáez, Itziar De Rojas, Marta Santos, Jesica Martín-Carmona, Anaïs Corma-Gómez, Alejandro González-Serna, José Luis Royo, Juan A. Pineda, Antonio Rivero, Antonio Rivero-Juárez, Juan Macías, Luis Miguel Real, The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study), Antiviral Research, Volume 222, 2024, 105795, ISSN 0166-3542, https://doi.org/10.1016/j.antiviral.2024.105795. (https://www.sciencedirect.com/science/article/pii/S0166354224000032) https://hdl.handle.net/10630/37186 10.1016/j.antiviral.2024.105795 Virus de la hepatitis C The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study).