2026-05-27T05:31:14Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/372362026-02-03T10:59:05Zcom_10630_2254col_10630_37953

Earlier diagnosis of lung cancer in a randomised trial of an autoantibody blood test followed by imaging Sullivan, Frank M. Mair, Frances S. Anderson, William Armory, Pauline Briggs, Andrew Chew, Cindy Dorward, Alistair Haughney, John Hogarth, Fiona Kendrick, Denise Littleford, Roberta McConnachie, Alex McCowan, Colin McMeekin, Nicola Patel, Manish Rauchhaus, Petra Ritchie, Lewis Robertson, Chris Robertson, John Robles-Zurita, José Antonio Sarvesvaran, Joseph Sewell, Herbert Sproule, Michael Taylor, Thomas Tello, Agnes Treweek, Shaun Vedhara, Kavita Schembri, Stuart Pulmón - Cáncer - Diagnóstico The EarlyCDT-Lung test is a high-specificity blood-based autoantibody biomarker that could contribute to predicting lung cancer risk. We report on the results of a phase IV biomarker evaluation of whether using the EarlyCDT-Lung test and any subsequent computed tomography (CT) scanning to identify those at high risk of lung cancer reduces the incidence of patients with stage III/IV/unspecified lung cancer at diagnosis compared with the standard clinical practice at the time the study began. The Early Diagnosis of Lung Cancer Scotland (ECLS) trial was a randomised controlled trial of 12 208 participants at risk of developing lung cancer in Scotland in the UK. The intervention arm received the EarlyCDT-Lung test and, if test-positive, low-dose CT scanning 6-monthly for up to 2 years. EarlyCDT-Lung test-negative and control arm participants received standard clinical care. Outcomes were assessed at 2 years post-randomisation using validated data on cancer occurrence, cancer staging, mortality and comorbidities. At 2 years, 127 lung cancers were detected in the study population (1.0%). In the intervention arm, 33 out of 56 (58.9%) lung cancers were diagnosed at stage III/IV compared with 52 out of 71 (73.2%) in the control arm. The hazard ratio for stage III/IV presentation was 0.64 (95% CI 0.41–0.99). There were nonsignificant differences in lung cancer and all-cause mortality after 2 years. ECLS compared EarlyCDT-Lung plus CT screening to standard clinical care (symptomatic presentation) and was not designed to assess the incremental contribution of the EarlyCDT-Lung test. The observation of a stage shift towards earlier-stage lung cancer diagnosis merits further investigations to evaluate whether the EarlyCDT-Lung test adds anything to the emerging standard of low-dose CT. 2025-01-29T07:53:22Z 2025-01-29T07:53:22Z 2020 journal article Sullivan, F. M., Mair, F. S., Anderson, W., Armory, P., Briggs, A., Chew, C., ... & Schembri, S. (2021). Earlier diagnosis of lung cancer in a randomised trial of an autoantibody blood test followed by imaging. European Respiratory Journal, 57(1). https://hdl.handle.net/10630/37236 https://doi.org/10.1183/13993003.00670-2020 eng open access EUROPEAN RESPIRATORY SOC JOURNALS LTD