2026-05-31T10:37:39Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/374012026-02-03T11:30:56Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Mates-Sánchez, José Manuel
author
Campos-Sandoval, José Ángel
author
Márquez-Gómez, Javier
2025-01-30T11:59:49Z
2025-01-30T11:59:49Z
2018-07
José M. Matés, José A. Campos-Sandoval, Javier Márquez, Glutaminase isoenzymes in the metabolic therapy of cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1870, Issue 2, 2018, Pages 158-164, ISSN 0304-419X, https://doi.org/10.1016/j.bbcan.2018.07.007. (https://www.sciencedirect.com/science/article/pii/S0304419X1830101X)
https://hdl.handle.net/10630/37401
10.1016/j.bbcan.2018.07.007
Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with malignancy of tumours. The two types of glutaminase isoenzymes, GLS and GLS2, differ in their expression patterns and functional roles: GLS has oncogenic properties and GLS2 has been described as a tumour suppressor factor. Selective genomic and epigenomic intervention over glutaminase affects the metabolic reprogramming of cancer. This review highlights the molecular metabolic vulnerabilities in various types of cancer, to be used for biomarker development, drug design, and in personalized oncology.
eng
Cáncer - Aspectos moleculares
Antiangiogénicos
Glutaminase isoenzymes in the metabolic 1 therapy of cancer
journal article
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URL
https://riuma.uma.es/bitstreams/5634b118-61de-4a05-87e5-b104517f1dda/download
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Matés et al.revised.pdf