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oai:riuma.uma.es:10630/375172026-02-03T11:33:00Zcom_10630_2254col_10630_37953

Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression. Laplana, Marina Bravo-Romero, María José Fernández-Fuertes, Marta Ruiz-García, Celia Alarcón-Martín, Emilio Colmenero Castillo, Juan de Dios Caruz-Arcos, Antonio Fibla, Joan Real-Navarrete, Luis Miguel Royo-Sánchez-Palencia, José Luis Infecciones por VIH Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its role in human immunodeficiency virus type 1 (HIV-1) infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation with a faster progression to the CD4+ < 200 cells/μL outcome for deletion allele carriers (Cox regression analysis: hazard ratio, 2.4 [95% confidence interval, 1.4–4]; P = .001). When naive patients with CD4+ < 200 cells/μL started antiretroviral treatment, rs111200466-deletion carriers showed a trend toward a slower, recovery rate (time required to reach CD4+ > 350 cells/μL; Cox P = .36). Our data suggest rs111200466 as a prognosis factor for HIV-1 disease progression. 2025-01-31T11:31:39Z 2025-01-31T11:31:39Z 2025-01-31T11:31:39Z 2020 journal article Marina Laplana, Maria Jose Bravo, Marta Fernández-Fuertes, Celia Ruiz-Garcia, Emilio Alarcón-Martin, Juan de Dios Colmenero, Antonio Caruz, Joan Fibla, Luis Miguel Real, Jose Luis Royo, Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression, The Journal of Infectious Diseases, Volume 222, Issue 12, 15 December 2020, Pages 2007–2011, https://doi.org/10.1093/infdis/jiaa327 https://hdl.handle.net/10630/37517 10.1093/infdis/jiaa327 eng open access Oxford Academy