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oai:riuma.uma.es:10630/376222026-02-03T10:58:31Zcom_10630_2254col_10630_37953

A revised electronic version of RUCAM for the diagnosis of DILI. Hayashi, PH Lucena-González, María Isabel Fontana, RJ Bjornsson, ES Aithal, GP Barnhart, H González-Jiménez, Andrés Yang, Q Gu, J Andrade-Bellido, Raúl Jesús Hoofnagle, JH Medicamentos - Toxicología RUCAM DILI RECAM REVISED ELECTRONIC VERSION DIAGNOSIS EVIDENCE BASED CAUSALITY ASSESSMENT Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network (DILIN) and the Spanish DILI Registry, published literature, and iterative computer modeling. The Drug-Induced Liver Injury (DILN) Network is structured as a U01 cooperative agreement with funds provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under grants: U24-DK065176 (Duke), U01-DK065201 (UNC), U01-DK065184 (Michigan), U01- DK065211 (Indiana), U01DK065193 (UConn), U01-DK065238 (UCSF/CPMC), U01-DK083023 (UTSW), U01-DK083027 (Einstein), U01-DK082992 (Mayo), U01-DK083020 (USC), U01-DK100928 (Mount Sinai). Additional support is provided by CTSA grants: UL1 RR025761 (Indiana), UL1TR000083 (UNC), UL1 RR024134 (UPenn), UL1 RR024986 (Michigan), UL1 RR024982 (UTSW), UL1 RR024150 (Mayo) and by the Intramural Research Program of the NIH, National Cancer Institute. Clinical Trials.gov number: NCT00345930. The Spanish DILI Registry is funded by grants of Instituto de Salud Carlos III cofounded by Fondo Europeo de Desarrollo Regional - FEDER (contract numbers PI 18/01804; PT 20/00127) and Agencia Española del Medicamento. Plataforma ISCiii de Investigación Clínica and CIBERehd are funded by ISCIII. 2016 American Association for the Study of Liver Disease (AASLD) Innovations Fund. 2025-02-03T10:28:29Z 2025-02-03T10:28:29Z 2022-07 journal article AM Hayashi PH, Lucena MI, Fontana RJ, Bjornsson ES, Aithal GP, Barnhart H, Gonzalez-Jimenez A, Yang Q, Gu J, Andrade RJ, Hoofnagle JH. A revised electronic version of RUCAM for the diagnosis of DILI. Hepatology. 2022 Jul;76(1):18-31. doi: 10.1002/hep.32327. Epub 2022 Mar 22. PMID: 35014066; PMCID: PMC9233102. https://hdl.handle.net/10630/37622 10.1002/hep.32327 eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf LIPPINCOTT WILLIAMS & WILKINS