2026-05-28T17:55:08Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/378242026-02-03T11:06:48Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Sarabia-García, Francisco Ramón author Vivar García, Carlos author García-Ruiz, Cristina author Sánchez-Ruiz, Antonio author Pino-González, María Soledad author García-Castro, Miguel author Chammaa, Samy author 2014-05 A new class of chiral sulfonium salts, derived from L- and D-methionine, has been designed and successfully employed in our laboratories for the diastereoselective synthesis of glycidic amides. The epoxy amides obtained were converted cleanly into 1,2-difunctionalized products through oxirane ring-opening reactions with different types of nucleophiles. The resulting ring-opened products represent valuable and useful building blocks for the synthesis of different bioactive products. Thus, the expedient synthesis of clavaminol H as well as the synthesis of key precursors for other bioactive compounds, for example, polyketide-derived natural products, have been achieved, demonstrating the synthetic efficiency and utility of this chemistry. Sarabia, F., Vivar-García, C., García-Ruiz, C., Sánchez-Ruiz, A., Pino-González, M.S., García-Castro, M., and Chammaa, S. (2024). Exploring the reactivity of chiral glycidic amides for their applications in synthesis of bioactive compounds. EurJOC 2014(18), 3847-3867 https://doi.org/10.1002/ejoc.201402221 https://hdl.handle.net/10630/37824 10.1002/ejoc.201402221 Compuestos bioactivos Exploring the reactivity of chiral glycidic amides for their applications in synthesis of bioactive compounds.