2026-06-06T02:15:52Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/381622026-02-03T11:08:14Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Di Zeo-Sánchez, Daniel Enrique author Segovia-Zafra, Antonio author Matilla-Cabello, Gonzalo author Pinazo-Bandera, José M. author Andrade-Bellido, Raúl Jesús author Lucena-González, María Isabel author Villanueva-Paz, Marina author 2022-09-16 Introduction Idiosyncratic drug-induced liver injury (iDILI) is a challenging and unpredictable multifactorial condition. At present, validated preclinical models for the prediction of the hepatotoxic potential of a given drug are scarce. Areas covered This review intends to sum up the current knowledge about in vitro (including hepatocyte 2D cultures, cocultures with non-parenchymal cells, 3D configurations and non-typical closer to reality in vitro models), in vivo (covering models for immunological and oxidative stress features, humanized mouse-based and non-rodent models) and in silico approaches for iDILI modeling, highlighting the recent advances in each topic. Expert opinion The future strategy for iDILI modeling should be patient-centered. Future animal and cell-based models, with more predictive value, will be easier to design by using a more translational approach based on mechanisms demonstrated in humans. Genetic and epigenetic information gathered from iDILI patients, together with data from in vitro and in vivo studies, could be used to develop sophisticated predictive in silico models to find compounds with iDILI potential. Collecting genetic, metabolic, and biomarker data from patient cohorts might be another option to create a ‘fingerprint’ characteristic of people at risk, allowing for the development of new, mechanistic strategies to enhance iDILI in vitro evaluation. Daniel E. Di Zeo-Sánchez, Antonio Segovia-Zafra, Gonzalo Matilla-Cabello, José M. Pinazo-Bandera, Raúl J. Andrade, M. Isabel Lucena & Marina Villanueva-Paz (2022) Modeling drug-induced liver injury: current status and future prospects, Expert Opinion on Drug Metabolism & Toxicology, 18:9, 555-573, DOI: 10.1080/17425255.2022.2122810 https://hdl.handle.net/10630/38162 10.1080/17425255.2022.2122810 Hepatotoxicidad - Aspectos genéticos Estrés oxidativo Hígado - Heridas y lesiones Modeling drug-induced liver injury: current status and future prospects.