2026-05-30T09:31:31Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/383452026-03-13T07:55:34Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Trujillo-Estrada, Laura Isabel author Gómez-Arboledas, Ángela author Forner, Stefania author Cadete Martini, Alessandra author Gutiérrez-Pérez, Antonia author Baglietto-Vargas, David author LaFerla, Frank M author 2019 Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and exocytosis, and synaptic transmission. Many of these functions are intrinsically related to neurodegeneration, allowing refocusing on the role of astrocytes in physiological and neurodegenerative states. Indeed, emerging evidence in the field indicates that abnormalities in the astrocytic function are involved in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD) and Amyotrophic Lateral Sclerosis (ALS). In the present review, we highlight the physiological role of astrocytes in the CNS, including their communication with other cells in the brain. Furthermore, we discuss exciting findings and novel experimental approaches that elucidate the role of astrocytes in multiple neurological disorders. Trujillo-Estrada L, Gomez-Arboledas A, Forner S, Martini AC, Gutierrez A, Baglietto-Vargas D, LaFerla FM. Astrocytes: From the physiology to the disease. Curr Alzheimer Res. 16(8):675-698. 2019. https://hdl.handle.net/10630/38345 10.2174/1567205016666190830110152 Sistema nervioso - Degeneración Neuroglia Astrocytes: From the physiology to the disease.