2026-06-03T22:30:47Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/383522026-03-13T07:35:19Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Trujillo-Estrada, Laura Isabel author Sánchez-Mejías, Elisabeth author Sánchez-Varo, Raquel María author García-León, Juan Antonio author Nuñez-Diaz, Cristina author Dávila-Cansino, José Carlos author Vitorica Ferrández, Javier author LaFerla, Frank author Moreno-González, Inés author Gutiérrez-Pérez, Antonia author Baglietto-Vargas, David author Baglietto-Vargas, David author 2022-12-06 Alzheimer’s disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms behind the clinical manifestations of AD. However, the limited ability of these in vivo models to accurately replicate the biology of the human disease have precluded the translation of promising preclinical therapies to the clinic. In this review, we highlight several major pathogenic mechanisms of AD that were discovered using transgenic mouse models. Moreover, we discuss the shortcomings of current animal models and the need to develop reliable models for the sporadic form of the disease, which accounts for the majority of AD cases, as well as human cellular models to improve success in translating results into human treatments. Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D. Animal and cellular models of Alzheimer’s disease: Progress, promise, and future approaches. Neuroscientist. 28(6):572-593. 2022 https://hdl.handle.net/10630/38352 10.1177/10738584211001753 Alzheimer, Enfermedad de - Modelos animales Animal and cellular models of Alzheimer’s disease: Progress, promise, and future approaches.