2026-05-31T05:48:12Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/386072026-02-03T11:21:07Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Rodríguez Capitán, Jorge author Márquez‑Camas, Paloma author Carmona‑Carmona, Jesús author Arroyo Moñino, Diego Félix author Chaparro‑Muñoz, Marinela author Soler‑González, Matías author García del Río, Manuel author Egido de la Iglesia, Teodora author Segovia‑Reyes, Jorge author Murri, Mora author López Salguero, José Raúl author Couto‑Mallón, David author Romero‑Cuevas, Miguel author Pavón-Morón, Francisco Javier author Gutiérrez-Bedmar, Mario author Jiménez‑Navarro, Manuel author 2025 Background Significant tricuspid regurgitation (TR) encompasses a wide range of etiologies, complicating a comprehensive understanding of disease progression and prognostic factors. This study aimed to assess mortality associated with significant TR, focusing on the role of valvular disease etiology and other predictive factors. Methods This is a retrospective, multicenter, cohort observational study, including all consecutive patients with moderate-to-severe or greater TR. The patients were classified into five etiological groups: organic TR, TR secondary to left valvu-lopathy, TR secondary to left or right ventricular dysfunction, TR secondary to pulmonary hypertension, and atrial TR. The long-term mortality was assessed (median follow-up: 39.8 months). Results 757 patients were included. The overall mortality incidence rate was 162.5 deaths per 1000 patient-years. Compared to atrial TR, all other etiologies presented a higher mortality risk: organic TR adjusted hazard ratio (aHR) = 2.344 (95% confidence interval [CI]: 1.138–4.829), left valvulopathy-related TR aHR = 1.901 (95% CI: 1.011–3.574), ventricular dysfunction-related TR aHR = 3.683 (95% CI: 1.627–8.338), and pulmonary hypertension-related TR aHR = 2.446 (95% CI: 1.215–4.927). In addition to known factors, male sex was associated with a higher mortality risk (aHR = 1.608, 1.175–2.201), while beta-blocker use was linked to a lower risk (aHR = 0.674, 0.502–0.904). Conclusions In a large cohort of patients with significant TR, and after adjusting for clinical and echocardiographic variables, all etiological groups exhibited a higher mortality risk compared to atrial TR. Additionally, male patients with TR had a higher mortality risk, while beta-blocker therapy emerged as a protective factor. Rodríguez-Capitán, J., Márquez-Camas, P., Carmona-Carmona, J. et al. Etiology of tricuspid regurgitation and mortality: a multicenter cohort study. Clin Res Cardiol (2025). https://doi.org/10.1007/s00392-025-02662-z https://hdl.handle.net/10630/38607 10.1007/s00392-025-02662-z Cardiología Válvula tricúspide Pronóstico médico Etiology of tricuspid regurgitation and mortality: a multicenter cohort study