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oai:riuma.uma.es:10630/386072026-02-03T11:21:07Zcom_10630_2254col_10630_37953

Etiology of tricuspid regurgitation and mortality: a multicenter cohort study Rodríguez Capitán, Jorge Márquez‑Camas, Paloma Carmona‑Carmona, Jesús Arroyo Moñino, Diego Félix Chaparro‑Muñoz, Marinela Soler‑González, Matías García del Río, Manuel Egido de la Iglesia, Teodora Segovia‑Reyes, Jorge Murri, Mora López Salguero, José Raúl Couto‑Mallón, David Romero‑Cuevas, Miguel Pavón-Morón, Francisco Javier Gutiérrez-Bedmar, Mario Jiménez‑Navarro, Manuel Cardiología Válvula tricúspide Pronóstico médico Background Significant tricuspid regurgitation (TR) encompasses a wide range of etiologies, complicating a comprehensive understanding of disease progression and prognostic factors. This study aimed to assess mortality associated with significant TR, focusing on the role of valvular disease etiology and other predictive factors. Methods This is a retrospective, multicenter, cohort observational study, including all consecutive patients with moderate-to-severe or greater TR. The patients were classified into five etiological groups: organic TR, TR secondary to left valvu-lopathy, TR secondary to left or right ventricular dysfunction, TR secondary to pulmonary hypertension, and atrial TR. The long-term mortality was assessed (median follow-up: 39.8 months). Results 757 patients were included. The overall mortality incidence rate was 162.5 deaths per 1000 patient-years. Compared to atrial TR, all other etiologies presented a higher mortality risk: organic TR adjusted hazard ratio (aHR) = 2.344 (95% confidence interval [CI]: 1.138–4.829), left valvulopathy-related TR aHR = 1.901 (95% CI: 1.011–3.574), ventricular dysfunction-related TR aHR = 3.683 (95% CI: 1.627–8.338), and pulmonary hypertension-related TR aHR = 2.446 (95% CI: 1.215–4.927). In addition to known factors, male sex was associated with a higher mortality risk (aHR = 1.608, 1.175–2.201), while beta-blocker use was linked to a lower risk (aHR = 0.674, 0.502–0.904). Conclusions In a large cohort of patients with significant TR, and after adjusting for clinical and echocardiographic variables, all etiological groups exhibited a higher mortality risk compared to atrial TR. Additionally, male patients with TR had a higher mortality risk, while beta-blocker therapy emerged as a protective factor. 2025-05-14T11:26:21Z 2025-05-14T11:26:21Z 2025 journal article Rodríguez-Capitán, J., Márquez-Camas, P., Carmona-Carmona, J. et al. Etiology of tricuspid regurgitation and mortality: a multicenter cohort study. Clin Res Cardiol (2025). https://doi.org/10.1007/s00392-025-02662-z https://hdl.handle.net/10630/38607 10.1007/s00392-025-02662-z eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Springer Nature