2026-05-30T07:01:14Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/386332026-02-03T11:34:30Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
De-la-Cruz-Cortés, José Pedro
author
Osuna-Esteban, Laura
author
Rodríguez-Pérez, María Dolores
author
Ortega-Hombrados, Laura
author
Sánchez Tévar, Ana María
author
Martín Aurioles, Esther
author
Fernández-Prior, María África
author
Pérez-Burillo, Sergio
author
Espejo-Calvo, Juan Antonio
author
González-Correa, José Antonio
2025-05-15T10:57:49Z
2025-05-15T10:57:49Z
2024-08-21
De La Cruz JP, Osuna-Esteban L, Rodríguez-Pérez MD, Ortega-Hombrados L, Sánchez-Tévar AM, Martín-Aurioles E, et al. Effect of a Triterpenoid-Rich Olive Oil on Chronic Kidney Disease in an Experimental Model of Diabetes Mellitus. Nutrients 2024, Vol 16, Page 2794. 2024;16:2794.
https://hdl.handle.net/10630/38633
10.3390/nu16162794
The aim of this study was to assess the effect of triterpenoids on the development of diabetic nephropathy in an experimental model of diabetes mellitus. For this purpose, a destoned and dehydrated olive oil (DDOO) was used, comparing its effects to a destoned olive oil (DOO). DDOO had a higher triterpenoid content than DOO but an equal content of alcoholic polyphenols. Four study groups (n = 10 animals/group) were formed: healthy rats, diabetic control rats (DRs), and DRs treated orally with 0.5 mL/kg/day of DOO or DDOO for two months. DRs showed impaired renal function (proteinuria, increased serum creatinine, decreased renal creatinine clearance) and morphology (glomerular volume and glomerulosclerosis). These alterations correlated with increased systemic and renal tissue oxidative stress and decreased prostacyclin production. DDOO administration significantly reduced all variables of renal damage, as well as systemic and renal oxidative stress, to a greater extent than the effect produced by DOO. In conclusion, triterpenoid-rich olive oil may prevent kidney damage in experimental diabetes mellitus
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Nefropatías diabéticas
Effect of a Triterpenoid-Rich Olive Oil on Chronic Kidney Disease in an Experimental Model of Diabetes Mellitus
journal article
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URL
https://riuma.uma.es/bitstreams/64833bea-b708-4432-abe6-3e6f4a1d44c2/download
File
MD5
380e75cc2876cc14eb8d83672515c30a
1863250
application/pdf
52 DM olive oil.pdf