2026-06-01T09:55:45Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/386542026-02-03T11:04:46Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc García-Barranquero, Pablo author Pérez-González, Saúl author 2025-05-05 Aging research is often framed within pluralistic frameworks that emphasize cellular and molecular damage processes. Among the most influential are Strategies for Engineered Negligible Senescence (SENS), which aims to counteract biological decline through targeted damage repair, and the Hallmarks of Aging (HoA), which seeks to identify fundamental mechanisms underlying this process. Both proposals, although diverse, significantly influence contemporary approaches to the challenges posed by aging. However, despite extensive discussion, we contend that key conceptual and methodological aspects remain insufficiently explored. This paper seeks to advance the debate by critically analyzing and comparing their foundational goals, theoretical premises, and research frameworks. Specifically, we examine their definitions of aging, perspectives on health and disease, approaches to scientific evidence and causal interventions, and communications strategies. In doing so, we aim to contribute to a deeper understanding and more nuanced assessment of both SENS and the HoA. García-Barranquero, P., Pérez-González, S. SENS vs. the hallmarks of aging: competing visions, shared challenges. Biogerontology 26, 103 (2025). https://doi.org/10.1007/s10522-025-10248-5 https://hdl.handle.net/10630/38654 10.1007/s10522-025-10248-5 Envejecimiento Gerontología SENS vs. the hallmarks of aging: competing visions, shared challenges