2026-06-01T08:38:14Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/386952026-02-03T11:36:21Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Sanz, Miriam author Gutiérrez- Díaz, Isabel author González, Héctor author Velasco Rodríguez‐Belvís, Marta author Picáns-Leis, Rosaura author Jiménez, Santiago author González-Jiménez, David author Rodríguez, Jorge author Queralt, Macarena author Herrador, Marta author Martin‐Masot, Rafael author Ferrer, Pablo author Navas-López, Víctor Manuel author Espín, Beatriz author Leis, Rosaura author Díaz, Juan J author Delgado, Susana author 2025-05 The SARS-CoV-2 virus and its rapid spread have made it a global health concern. The aim of this was to investigate the microbial and metabolic faecal profiles of paediatric patients hospitalised for COVID-19 to try to identify biomarkers of predisposition to severity. The study included 16 patients (aged 4–14 years old) from six different Spanish hospitals and 20 age-matched healthy controls. The gut microbiota was characterised by sequencing of 16S rDNA amplicons and internal transcribed space amplicons, while the metabolic profile was analysed by liquid chromatography high resolution mass spectrometry. A different microbial profile was observed between patients and controls, with a significantly higher abundance of sequences belonging to the phyla Bacteroidota and Pseudomonadota in patients. A different metabolic profile was observed between the two groups. Non-infected children had higher faecal levels of vitamins such as niacin, thiamine, and vitamin D3 derivatives, which were negatively correlated with the abundance of pathogenic bacteria, such as members of Enterobacteriaceae. Hospitalisation due to SARS-CoV-2 infection in children was associated with changes in the gut microbiota and an altered metabolomic profile. For the first time, several relevant biological compounds were found to be reduced in the faeces of children hospitalised with COVID-19 compared to healthy controls. Sanz M, Gutiérrez-Diaz I, González H, Rodríguez-Belvís MV, Picáns-Leis R, Jiménez S, et al. (2025) Hospitalised children with COVID-19 display an aberrant intestinal microbiota and a shift in faecal compounds related with the metabolism of vitamins and lipids. PLoS One 20(5): e0323910 https://hdl.handle.net/10630/38695 10.1371/journal.pone.0323910 Niños - Efectos de la COVID-19 Flora intestinal - Investigación Hospitalised children with COVID-19 display an aberrant intestinal microbiota and a shift in faecal compounds related with the metabolism of vitamins and lipids