2026-06-06T19:14:01Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/389412026-04-10T08:28:47Zcom_10630_2254col_10630_37953

Huércano Rubens, Carolina Moya-Barrientos, Miriam Cuevas Corral, Oliver Sánchez-Vera, Victoria Ruiz-López, Noemí 2025-06-09T11:02:12Z 2025-06-09T11:02:12Z 2025-05-22 Huercano C, Moya-Barrientos M, Cuevas O, Sanchez-Vera V, Ruiz-Lopez N. ER-plastid contact sites as molecular crossroads for plastid lipid biosynthesis. BMC Biol. 2025 May 22;23(1):139. doi: 10.1186/s12915-025-02239-2. PMID: 40405194; PMCID: PMC12096540. https://hdl.handle.net/10630/38941 10.1186/s12915-025-02239-2 Membrane contact sites are specialized regions where organelle membranes are in close proximity, enabling lipid transfer while preserving membrane identity. In plants, ER‒chloroplast contact sites are critical for maintaining glycerolipid homeostasis. This review examines the lipid-modifying and lipid-transfer proteins/complexes involved in these processes. Key proteins at these sites, including components of the TGD and VAP27‒ORP2A complexes, as well as Sec14 proteins, facilitate lipid exchange. Additionally, the roles of lipid-modifying proteins at these contact sites are discussed. Despite significant progress, further research is needed to identify additional proteins, investigate ER‒chloroplast dynamics under stress and explore ER contact sites in non-chloroplast plastids. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Membranas (Biología) Lípidos de membrana Retículo endoplásmico ER-plastid contact sites as molecular crossroads for plastid lipid biosynthesis journal article