2026-05-30T02:14:34Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/389822026-02-03T10:49:35Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Carmona-Mejías, Rita María
author
López-Sánchez, Carmen
author
García-Martínez, Virginio
author
García-López, Virginio
author
Muñoz-Chápuli-Oriol, Ramón
author
Lozano-Velasco, Estefanía
author
Franco, Diego
2025-06-13T08:39:28Z
2025-06-13T08:39:28Z
2023
Carmona, R.; López- Sánchez, C.; Garcia-Martinez, V.; Garcia-López, V.; Muñoz-Chápuli, R.; Lozano-Velasco, E.; Franco, D. Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation. J. Cardiovasc. Dev. Dis. 2023, 10, 440. https:// doi.org/10.3390/jcdd10110440
https://hdl.handle.net/10630/38982
10.3390/jcdd10110440
The embryonic epicardium originates from the proepicardium, an extracardiac primordium
constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized
by a squamous cell epithelium resting on the myocardium surface. Subsequently, it invades the
subepicardial space and thereafter the embryonicmyocardiumbymeans of an epithelial–mesenchymal
transition.Within the myocardium, epicardial-derived cells present multilineage potential, later differentiating
into smoothmuscle cells and contributing both to coronary vasculature and cardiac fibroblasts
in themature heart. Over the last decades, we have progressively increased our understanding of those
cellular and molecular mechanisms driving proepicardial/embryonic epicardium formation. This
study provides a state-of-the-art review of the transcriptional and emerging post-transcriptional
mechanisms involved in the formation and differentiation of the embryonic epicardium.
eng
Transcripción genética - Regulación
Corazón - Embriología
Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation.
journal article
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Carmona-Franco 2023.pdf