2026-06-06T02:14:04Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/389822026-02-03T10:49:35Zcom_10630_2254col_10630_37953

Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation. Carmona-Mejías, Rita María López-Sánchez, Carmen García-Martínez, Virginio García-López, Virginio Muñoz-Chápuli-Oriol, Ramón Lozano-Velasco, Estefanía Franco, Diego Transcripción genética - Regulación Corazón - Embriología The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium surface. Subsequently, it invades the subepicardial space and thereafter the embryonicmyocardiumbymeans of an epithelial–mesenchymal transition.Within the myocardium, epicardial-derived cells present multilineage potential, later differentiating into smoothmuscle cells and contributing both to coronary vasculature and cardiac fibroblasts in themature heart. Over the last decades, we have progressively increased our understanding of those cellular and molecular mechanisms driving proepicardial/embryonic epicardium formation. This study provides a state-of-the-art review of the transcriptional and emerging post-transcriptional mechanisms involved in the formation and differentiation of the embryonic epicardium. 2025-06-13T08:39:28Z 2025-06-13T08:39:28Z 2025-06-13T08:39:28Z 2023 journal article Carmona, R.; López- Sánchez, C.; Garcia-Martinez, V.; Garcia-López, V.; Muñoz-Chápuli, R.; Lozano-Velasco, E.; Franco, D. Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation. J. Cardiovasc. Dev. Dis. 2023, 10, 440. https:// doi.org/10.3390/jcdd10110440 https://hdl.handle.net/10630/38982 10.3390/jcdd10110440 eng open access MDPI