2026-06-01T16:03:14Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/392532026-02-03T11:11:47Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Masmudi-Martín, Mariam
author
Navarro-Lobato, Irene
author
López-Aranda, Manuel Francisco
author
Browning, Philip G. F.
author
Simon, Ana María
author
López-Téllez, Juan Félix
author
Jiménez Recuerda, Inmaculada
author
Martín-Montañez, Elisa
author
Pérez-Mediavilla, Alberto
author
Frechilla, Diana
author
Baxter, Mark G.
author
Khan, Zafaruddin
2025-07-08T06:41:09Z
2025-07-08T06:41:09Z
2020-09-06
Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, et al. Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer's Diseases. Neuroscience. 2020;448:287-298. doi:10.1016/j.neuroscience.2020.08.039
https://hdl.handle.net/10630/39253
10.1016/j.neuroscience.2020.08.039
The integrity of the perirhinal cortex (PRh) is essential for object recognition memory (ORM) function, and damage to this brain area in animals and humans induces irreversible ORM deficits. Here, we show that activation of area V2, a brain area interconnected with brain circuits of ventral stream and medial temporal lobe that sustain ORM, by expression of regulator of G-protein signaling 14 of 414 amino acids (RGS14414) restored ORM in memory-deficient PRh-lesioned rats and nonhuman primates. Furthermore, this treatment was sufficient for full recovery of ORM in rodent models of aging and Alzheimer's disease, conditions thought to affect multiple brain areas. Thus, RGS14414-mediated activation of area V2 has therapeutic relevance in the recovery of recognition memory, a type of memory that is primarily affected in patients or individuals with symptoms of memory dysfunction. These findings suggest that area V2 modulates the processing of memory-related information through activation of interconnected brain circuits formed by the participation of distinct brain areas.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Alzheimer, Enfermedad de - Modelos animales
Memoria - Trastornos
Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer’s Diseases
journal article
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2020- Masmudi-Martin...Lopez Aranda.pdf