2026-06-02T21:40:47Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/393852026-02-03T11:10:13Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Soria-Utrilla, Virginia
author
Sasso, Corina Verónica
author
Romero-Zerbo, Silvana Yanina
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Adarve-Castro, Antonio
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López-Urdiales, Rafael
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Herranz-Antolín, Sandra
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García-Almeida, José Manuel
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García-Malpartida, Katherine
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Ferrer-Gómez, Mercedes
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Moreno-Borreguero, Alicia
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Luengo-Pérez, Luis Miguel
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Álvarez-Hernández, Julia
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Aragón-Valera, Carmen
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Ocón-Bretón, María Julia
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García-Manzanares, Álvaro
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Bretón-Lesmes, Irene
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Serrano-Aguayo, Pilar
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Pérez-Ferre, Natalia
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López-Gómez, Juan José
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Olivares-Alcolea, Josefina
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Moreno-Martínez, Macarena
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Tejera-Pérez, Cristina
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García-Arias, Sara
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García-Arias, Sara
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Abad-González, Ángel Luis
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Alhambra-Expósito, María Rosa
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Zugasti-Murillo, Ana
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Parra-Barona, Juan
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Torrejón-Jaramillo, Sara
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Abuin, José
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Fernández-García, José C.
author
Olveira-Fuster, Gabriel María
2025-07-17T09:28:57Z
2025-07-17T09:28:57Z
2025
Soria-Utrilla, V., Sasso, C. V., Romero-Zerbo, S. Y., Adarve-Castro, A., López-Urdiales, R., Herranz-Antolín, S., García-Almeida, J. M., García-Malpartida, K., Ferrer-Gómez, M., Moreno-Borreguero, A., Luengo-Pérez, L. M., Álvarez-Hernández, J., Aragón-Valera, C., Ocón-Bretón, M. J., García-Manzanares, Á., Bretón-Lesmes, I., Serrano-Aguayo, P., Pérez-Ferre, N., López-Gómez, J. J., . . . Olveira, G. (2024). Biomarkers of Oxidation, Inflammation and Intestinal Permeability in Persons with Diabetes Mellitus with Parenteral Nutrition: a Multicenter Randomized Trial. Clinical Nutrition, 44, 155-164. https://doi.org/10.1016/j.clnu.2024.11.044
https://hdl.handle.net/10630/39385
10.1016/j.clnu.2024.11.044
Background and aims: Parenteral nutrition (PN) composition could play a role in the management of systemic inflammatory response and intestinal barrier disruption. We aimed to evaluate changes in biomarkers of inflammation, oxidative status and intestinal permeability in patients with type 2 diabetes mellitus (T2DM) who received different PN lipid formulas. Methods: This was a prospective study, including 94 patients with T2DM who received omega (n)-3 polyunsaturated fatty acids (PUFA)-enriched PN, a mixture of medium and long chain triglycerides (MCT/ LCT) PN, or an olive oil-based PN. Serum levels of biomarkers of oxidative status, intestinal permeability and inflammation biomarkers were determined at day 1 and day 5 after PN initiation. Registered under ClinicalTrials.gov Identifier no. NCT02706119.Results: At day 5 after the onset of PN, the MCT/LCT group had a significant reduction of 2 proinflammatory cytokines [interleukin (IL)-15, IL-17A], elevation of the anti-inflammatory cytokine IL-13 and increase of zonulin and indoxylsulfate. The olive oil group showed a statistically significant reduction of 5 proinflammatory cytokines [IL-1b, IL-17A, IL-6, cytokine-leukemia inhibitory factor (LIF) and tumor necrosis factor alpha (TNF-a)] and reduced concentrations of the anti-inflammatory cytokine IL-1RA, while the n-3 PUFA-enriched group presented a statistically significant reduction of 8 proinflammatory cytokines (interferon-gamma, IL-1b, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, and TNF-a). In the between-group comparisons, indoxylsulfate significantly increased in the MCT/LCT group compared to the n-3 PUFA-enriched group, while 8-isoprostane and indoxylsulfate significantly increased in the MCT/LCT group compared to the other groups and superoxide dismutase significantly decreased in the MCT/LCT group compared to the other groups. Conclusion: In patients with T2DM, PN lipid composition exerts a profound impact on proinflammatory, prooxidative and intestinal permeability biomarkers
eng
Attribution 4.0 Internacional
Alimentación parenteral
Inflamación (Patología)
Intestinos
Diabetes tipo 2
Biomarkers of oxidation, inflammation and intestinal permeability in persons with diabetes mellitus with parenteral nutrition: A multicenter randomized trial
journal article
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https://riuma.uma.es/bitstreams/37885cbe-5c18-4c02-a46b-534bc940bb42/download
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78ce6ca50466748c90449ea3a513c6f8
1032022
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