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oai:riuma.uma.es:10630/393852026-02-03T11:10:13Zcom_10630_2254col_10630_37953

Soria-Utrilla, Virginia Sasso, Corina Verónica Romero-Zerbo, Silvana Yanina Adarve-Castro, Antonio López-Urdiales, Rafael Herranz-Antolín, Sandra García-Almeida, José Manuel García-Malpartida, Katherine Ferrer-Gómez, Mercedes Moreno-Borreguero, Alicia Luengo-Pérez, Luis Miguel Álvarez-Hernández, Julia Aragón-Valera, Carmen Ocón-Bretón, María Julia García-Manzanares, Álvaro Bretón-Lesmes, Irene Serrano-Aguayo, Pilar Pérez-Ferre, Natalia López-Gómez, Juan José Olivares-Alcolea, Josefina Moreno-Martínez, Macarena Tejera-Pérez, Cristina García-Arias, Sara García-Arias, Sara Abad-González, Ángel Luis Alhambra-Expósito, María Rosa Zugasti-Murillo, Ana Parra-Barona, Juan Torrejón-Jaramillo, Sara Abuin, José Fernández-García, José C. Olveira-Fuster, Gabriel María 2025-07-17T09:28:57Z 2025-07-17T09:28:57Z 2025 Soria-Utrilla, V., Sasso, C. V., Romero-Zerbo, S. Y., Adarve-Castro, A., López-Urdiales, R., Herranz-Antolín, S., García-Almeida, J. M., García-Malpartida, K., Ferrer-Gómez, M., Moreno-Borreguero, A., Luengo-Pérez, L. M., Álvarez-Hernández, J., Aragón-Valera, C., Ocón-Bretón, M. J., García-Manzanares, Á., Bretón-Lesmes, I., Serrano-Aguayo, P., Pérez-Ferre, N., López-Gómez, J. J., . . . Olveira, G. (2024). Biomarkers of Oxidation, Inflammation and Intestinal Permeability in Persons with Diabetes Mellitus with Parenteral Nutrition: a Multicenter Randomized Trial. Clinical Nutrition, 44, 155-164. https://doi.org/10.1016/j.clnu.2024.11.044 https://hdl.handle.net/10630/39385 10.1016/j.clnu.2024.11.044 Background and aims: Parenteral nutrition (PN) composition could play a role in the management of systemic inflammatory response and intestinal barrier disruption. We aimed to evaluate changes in biomarkers of inflammation, oxidative status and intestinal permeability in patients with type 2 diabetes mellitus (T2DM) who received different PN lipid formulas. Methods: This was a prospective study, including 94 patients with T2DM who received omega (n)-3 polyunsaturated fatty acids (PUFA)-enriched PN, a mixture of medium and long chain triglycerides (MCT/ LCT) PN, or an olive oil-based PN. Serum levels of biomarkers of oxidative status, intestinal permeability and inflammation biomarkers were determined at day 1 and day 5 after PN initiation. Registered under ClinicalTrials.gov Identifier no. NCT02706119. Results: At day 5 after the onset of PN, the MCT/LCT group had a significant reduction of 2 proinflammatory cytokines [interleukin (IL)-15, IL-17A], elevation of the anti-inflammatory cytokine IL-13 and increase of zonulin and indoxylsulfate. The olive oil group showed a statistically significant reduction of 5 proinflammatory cytokines [IL-1b, IL-17A, IL-6, cytokine-leukemia inhibitory factor (LIF) and tumor necrosis factor alpha (TNF-a)] and reduced concentrations of the anti-inflammatory cytokine IL-1RA, while the n-3 PUFA-enriched group presented a statistically significant reduction of 8 proinflammatory cytokines (interferon-gamma, IL-1b, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, and TNF-a). In the between-group comparisons, indoxylsulfate significantly increased in the MCT/LCT group compared to the n-3 PUFA-enriched group, while 8-isoprostane and indoxylsulfate significantly increased in the MCT/LCT group compared to the other groups and superoxide dismutase significantly decreased in the MCT/LCT group compared to the other groups. Conclusion: In patients with T2DM, PN lipid composition exerts a profound impact on proinflammatory, prooxidative and intestinal permeability biomarkers eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 Internacional Alimentación parenteral Inflamación (Patología) Intestinos Diabetes tipo 2 Biomarkers of oxidation, inflammation and intestinal permeability in persons with diabetes mellitus with parenteral nutrition: A multicenter randomized trial journal article