2026-06-02T12:46:01Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/394312026-02-03T11:07:40Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Nestares, Teresa
author
Jiménez Muñoz, María
author
Torcuato-Rubio, Encarnación
author
Tamayo Pérez, Laura
author
De La Flor Alemany, Marta
author
Herrador-López, Marta
author
Navas-López, Víctor Manuel
author
Martin‐Masot, Rafael
2025-07-21T12:02:42Z
2025-07-21T12:02:42Z
2025
Nestares T, Jiménez-Muñoz M, Torcuato-Rubio E, Tamayo Pérez L, de la Flor Alemany M, Herrador-López M, Navas-López V, Martín-Masot R. Cellular Recovery and Body Composition Changes in Pediatric Celiac Disease After the Start of a Gluten-Free Diet: A Prospective Cohort Study. Journal of Clinical Medicine. 2025; 14(14):5061.
https://hdl.handle.net/10630/39431
10.3390/jcm14145061
Background/Objectives: Celiac disease (CD) alters nutrient absorption and body composi-
tion, especially during childhood. Although adherence to a gluten-free diet (GFD) promotes
mucosal recovery, its impact on cellular functionality and metabolic balance remains under-
explored. This study aims to evaluate the utility of bioelectrical impedance vector analysis
(BIVA) in assessing nutritional status, inflammatory improvement, and body composition
changes in pediatric patients with CD following a GFD. Methods: Seventy-nine children
aged 5–14 years were studied. Three groups were analyzed: (1) 25 children with newly
diagnosed CD, evaluated at diagnosis and after 12 months of GFD (prospective cohort);
(2) 25 CD patients on a GFD for over 24 months (cross-sectional); and (3) 29 healthy controls.
Body composition (fat mass (FM), fat-free mass (FFM), body cell mass (BCM), phase angle
(PhA), and Na+/K+
ratio) was measured. GFD adherence was assessed and a dietary
assessment was also performed. Results: After 12 months on a GFD, newly diagnosed CD
patients showed significant increases in FM (from 8.2 to 10.1 kg, p = 0.001), FFM (p = 0.001),
and BCM (p = 0.0001), along with a significant decrease in the Na+/K+
ratio (p = 0.015).
Compared to healthy controls, CD children on GFD for more than 24 months had higher
FM (12.2 vs. 8.8 kg, p = 0.013) and lower Na+/K+
ratios (p = 0.006). PhA increased slightly
over time but did not reach statistical significance. Conclusions: Our study suggests that
the adherence to a GFD leads to improved body composition and cellular homeostasis in
children with CD, as reflected by increases in BCM and reductions in Na+/K+
ratio, making
it a promising biomarker for monitoring inflammation and cellular recovery.
eng
Attribution 4.0 Internacional
Enfermedad celíaca en niños
Dietas sin gluten
Cuerpo humano - Composición
Cellular recovery and body composition changes in pediatric celiac disease after the start of a gluten-free diet: a prospective cohort study
journal article
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